The 2021 AI4SE/SE4AI Workshop will be held October 20-21 virtually on ZoomGov. Participation is limited to US citizens only and will be by invitation. Abstracts are sought for presentations and panels from government, industry and academia addressing key Artificial Intelligence (AI) and Systems Engineering (SE) initiatives. All abstracts and presentations must be approved for public release. Selected abstracts will be invited to present and/or attend the workshop.