The Systems Engineering Research Center is pleased to announce a call for abstracts for the sixth annual AI4SE & SE4AI Workshop being held on September 17-18, 2025. The event will be held at the Virginia Tech Innovation Campus in Alexandria, Virginia. This highly anticipated event will bring together academia, government, and industry experts to explore the exciting advancements and challenges in the field of artificial intelligence (AI) and systems engineering (SE). All selected abstracts and presentations must be approved for public release.