The First IEEE International Symposium on Systems Engineering (ISSE) will be held at the Rome Marriott Park Hotel in Rome, Italy on September 28-30, 2015. This symposium seeks to create an interactive forum for the practice of systems engineering across the multiple disciplines and specialty areas associated with the engineering of complex systems. The symposium will provide a venue for systems engineering practitioners, managers, researchers, and educators to exchange innovative concepts, ideas, applications and lessons learned addressing: Applications-oriented topics on large-scale systems and systems-of-systems…