Systems engineering is undergoing a transformation motivated by mission and system complexity, and enabled by technological advances such as model-based systems engineering, digital engineering, formal modeling, and the convergence of systems engineering with other disciplines. This conference is focused on exploring recent trends and advances in model-based systems engineering (MBSE) and the synergy of MBSE with simulation technology and digital engineering. Researchers have submitted papers on MBSE methods, modeling approaches, standards, languages, and economics analysis to respond to the challenges posed by 21st century systems.